Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101)
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چکیده
منابع مشابه
Methyl 4-(butyrylamino)-5-methyl-2-nitrobenzoate
The title compound, C(13)H(16)N(2)O(5), is useful as an inter-mediate in the field of agrochemicals. Intra-molecular C-H⋯O hydrogen bonds result in the formation of one six- and one five-membered nearly planar ring; the six-membered ring is also nearly coplanar with the adjacent benzene ring. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link the mol-ecules.
متن کامل{5-Methyl-1-[8-(trifluoromethyl)quinolin-4-yl]-1H-1,2,3-triazol-4-yl}(morpholino)methanone
In the title mol-ecule, C(18)H(16)F(3)N(5)O(2), the dihedral angle between the pyridine ring and the fused benzene ring is 4.50 (10)°. The triazole ring makes dihedral angles of 54.48 (12) and 57.91 (11)° with the pyridine and benzene rings, respectively. The morpholine ring atoms are disordered over two positions; the site-occupancy factors are ca 0.53 and 0.47. Inter-molecular C-H⋯F hydrogen ...
متن کاملrac-tert-Butyl 2-{5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-2,4-dioxo-1,3-thiazolidin-3-yl}acetate
The title compound, C(24)H(29)N(3)O(5)S, is a chiral mol-ecule which crystallizes in a centrosymmetric space group as a racemate. The thia-zolidine ring forms the dihedral angles of 29.22 (12) and 67.79 (10)° with the benzene and pyridine rings, respectively. The benzene and pyridine rings are tilted by dihedral angle of 67.18 (9)°. In the crystal, inter-molecular C-H⋯O hydrogen bonds link the ...
متن کاملRelaxant effect of 7-ethoxy-4-methyl-2H-chromen-2-one by calcium channel blockade: computational and ex vivo studies
Amanda Sánchez-Recillas, Gabriel Navarrete-Vázquez, César Millán-Pacheco, Berenice Aguilar-Guadarrama, Rolffy Ortiz-Andrade, Samuel Estrada-Soto Facultad de Farmacia, Facultad de Ciencias and Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, México. Facultad de Química, Universidad Autónom...
متن کاملPharmacological studies and synthesis of morpholino alkyl derivatives.
Seven morpholin derivatives were synthesized (compounds 1-7) and their behavioural effects were evaluated; the elements considered were locomotor activity, motor coordination, catalepsy, stereotyped behaviour and antinociception. All the compounds, at doses of 10-20-40 mg/kg/i.p., induced a reduction of all behavioural elements without a significant antinociceptive effect. These results indicat...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1979
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.75.291